There are hundreds of different cannabinoids present inside the cannabis plant, but the two most commonly found are CBD (cannabidiol) and THC (tetrahydrocannabinol). Due to their differences in characteristics, some believe that CBD can negate the effects of THC when consumed together.

As it’s still a relatively new field of study, research has shown mixed results and there’s no conclusive evidence of this statement. In this blog post, we’ll discuss CBD and THC, share recent findings, and discuss some practical considerations you can take into account.

Understanding CBD and THC

As mentioned earlier, CBD and THC are two of the most commonly found cannabinoids in the cannabis plant. One of the main differences between CBD and THC is that pure CBD does not produce psychoactive effects while THC does.

Both of these compounds react with our endocannabinoid system or ECS, which has an important role in maintaining our body’s homeostasis, which is a state of balance. The ECS includes three different components: endocannabinoids, cannabinoid receptors, and enzymes.

THC interacts with our ECS by binding to CB1 and CB2 receptors. It has greater affinity with CB1 receptors that are primarily located in our central nervous system, resulting in the psychoactive effects or “high” when consumed. On the other hand, CBD has a greater affinity to the CB2 receptors.

Although both could potentially have beneficial effects* when consumed on their own, it’s believed that various cannabinoids can give greater physical or psychological effects when they’re working together.

This synergy is called the entourage effect and it was first mentioned when it was found that a whole cannabis plant extract had more effects than any one cannabinoid alone. The entourage effect further complicates our understanding of how CBD and THC interact in our bodies, and there is still no clear evidence on how the entourage effect works or if THC and CBD are solely responsible for it, thus further clinical trials are still needed.

The Debate: Does CBD “Cancel” THC?

Some studies have shown that CBD can mitigate THC’s negative effects. An earlier study found that CBD can suppress THC’s psychosis and anxiety-inducing effects when consumed together.

Others have found that CBD balances part of THC-induced effects, creating protection against impairment and other negative psychotic symptoms.

Another important role that the CBD:THC ratio potentially may have is mitigating the risk of addiction. Although a higher CBD content leads to diminished appreciation, it was concluded that more CBD means a lower probability of developing an addiction.

On the other hand, recent studies have found otherwise. One particular research found no evidence that CBD significantly modulated THC’s acute effects. In the study, the test subjects were given different types of cannabis like pure THC, THC+CBD, and a placebo. Both THC and THC+CBD groups exhibited increased ‘feel drug effect’, impaired memory, and increased psychotomimetic effects.

Another study using four different CBD:THC ratios in cannabis products has also found no evidence that CBD can protect against adverse effects of cannabis. The subjects were administered with 0:1, 1:1, 2:1, or 3:1 ratios, and there were no differences in cognitive, psychotic, subjective, pleasurable, and physiological measures.

It’s hard to conclude how these cannabinoids affect each other, especially since their interaction is also determined by several different factors, such as individual body chemistry, consumption method, and dosage.

The Role of CBD:THC Ratios in Cannabis Consumption

Different CBD:THC ratios create different effects during cannabis consumption. One important aspect of regulating the ratio is to manage unwanted effects, such as intoxication.

A good combination of both CBD and THC may lead to an “entourage effect”. The term refers to the suggested positive contribution of combining two different cannabinoids, THC and CBD.

Several common ratios found in products are as follows:

  • 20:1, high CBD and low THC ratio. This ratio can give you minimal psychoactive effects while still having the benefits of the entourage effect which is ideal for beginners.
  • 10:1, high CBD and medium THC ratio. This ratio will still modulate THC with a high CBD concentration.
  • 5:1, medium CBD and medium THC ratio. This ratio is ideal for those who have a higher tolerance to THC.
  • 1:1, equal amounts of CBD and THC. The high concentration of THC means the use of cannabis will lead to stronger psychoactive effects.

Practical Considerations for Cannabis Consumers

There are several ratios of CBD:THC that you can pick. Your choice depends on your experience and objective. These are several considerations you should take into account before choosing the right ratio.

The objective behind your consumption – Some users might call for a lower concentration of THC to mitigate psychoactive reactions. On the other hand, you’ll need a high amount of THC to help feel more relaxed.

Your experience in cannabis consumption – Beginners will find it better to start with lower doses and gradually adjust according to your tolerance.

Remember that everyone reacts to cannabinoids differently. You can try and experiment on your own to see how your body responds to the effects of CBD and THC. Adjust the concentrations accordingly and consult a medical professional if needed to avoid unwanted side effects.

Conclusion

Some studies suggest consuming CBD with THC could mitigate the adverse effects of THC. On the other hand, recent studies found that introducing CBD into THC consumption didn’t affect any adverse reaction.

This might be because other factors could come into play, such as dosage, existing tolerance, or consumption method. Further research is still needed to understand how CBD and THC interact, and how they can impact our health overall.

CBD and THC FAQs

Can CBD prevent the psychoactive effects of THC?

There are still mixed results on how CBD might affect THC’s psychoactive effects. Previous studies suggested CBD can reduce the psychoactive effects of THC, while recent ones showed it did not alter it at all. Further research is still needed on a bigger scale to conclude on the matter.

What are the common CBD:THC ratios and their effects?

The common ratios of CBD:THC are 20:1, 10:1, 5:1, and 1:1. The lower concentrations of THC at 20:1 and 10:1 are great for those who are looking to modulate THC’s psychoactive effects.

How do CBD and THC interact within the endocannabinoid system?

CBD and THC interact with the endocannabinoid system by interacting with our CB1 and CB2 receptors, which could affect our body’s state of balance called homeostasis. Their difference in reaction leads to differing effects on our bodies.

Is it possible to counteract a THC high by taking CBD?

The findings on CBD’s counteractive effects on the psychoactivity of THC are still inconclusive. Previous research found that CBD can counteract it, but these results have not been consistent. You should always consult a medical professional and start with low doses to see how you respond to marijuana use.

How should one determine the ideal CBD:THC ratio for their needs?

The ideal ratio will depend on your objective and experience. Beginners can benefit from starting at lower doses, and then adjust accordingly to their desired outcomes.

Does the method of consumption (inhaling vs. oral) affect how CBD influences THC’s effects?

Method of consumption can impact the interaction of CBD and THC in your body. The bioavailability of both THC and CBD is higher when consumed via inhalation, leading to faster and more intense reactions. Edibles on the other hand, take a while to kick in but the effects are known to last longer, especially in high doses.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The use of CBD is now widely accepted, and the powerful compound is skyrocketing in popularity. Over the last four years, CBD use has increased 50% according to the Journal of the American Medical Association.

One of the factors supporting its growth is the 2018 Farm Bill that legalized hemp products. Now, you can find CBD in different products, such as tinctures, edibles, vapes, and topical lotions.

An important part of processing CBD products is extraction. The proper extraction method will retain CBD’s potency, separating it from the plant and creating a more concentrated product without contaminants.

In this blog post, we’ll look at the various CBD extraction processes and how they significantly affect the final quality of your CBD products.

Understanding CBD

Cannabidiol or CBD, is the second most abundant active compound in the cannabis plant. It can be derived directly from hemp plants or manufactured in a laboratory. A specific characteristic of CBD that separates it from other active compounds in marijuana is its non-psychoactive nature. Unlike its cousin THC, CBD does not cause a “high” by itself.

It should be noted that the field of CBD is still evolving, and further research is needed for conclusive findings.

Overview of CBD Extraction Methods

CBD is one part that’s available in a myriad of hemp compounds, that’s why it needs further processing to isolate the final product. There are several methods of extracting CBD, each with its benefits and downsides.

In general, there are four different methods of extraction: CO2, Ethanol, Hydrocarbon, and Olive Oil extractions. Manufacturers will choose one based on efficiency, costs, results, and other factors. In this section, we’ll give you some insights into each method to show you which will result in the best CBD quality.

Detailed Exploration of Extraction Methods

CO2 Extraction

Extractions generally use natural solvents to separate desired compounds like terpenes or CBD from others and carbon dioxide, CO2, is the solvent in this particular method. To make CO2 a powerful solvent, you need to expose it to extreme temperature and pressure.

There are two different CO2 solvent extraction methods: subcritical and supercritical. Subcritical is when a lower temperature is used and CO2 is in liquid form, while supercritical requires a higher temperature and CO2 is in gas form.

CO2 extraction systems results in pure and eco-friendly concentrates, leading to high-quality products. It’s a slower process and needs certain conditions, which is why it’s more expensive and requires skilled technicians.

At NuLeaf Naturals, this is our method of choice, because we believe purity is one of the most important aspects of high-quality CBD and it should be the industry standard.

Ethanol Extraction

Another method that’s used in the industry is ethanol extraction. There are two different ethanol extraction methods: cold and warm.

The warm ethanol extraction is generally used for smaller batches, as it can quickly wash the plant material to pull the compounds. The cold extraction method works by freezing undesirable materials to pull the desirable compound into ethanol.

Ethanol extraction is a simpler, more affordable, and faster method compared to CO2. On the other hand, it can dissolve other water-soluble compounds such as chlorophyll. In the end, the extract is not as pure as the ones from CO2 extraction.

Hydrocarbon Extraction

In hydrocarbon extraction, you’ll use certain hydrocarbons as your solvent. Butane is the most popular solvent in the industry as it has a low boiling point. The solvent is combined with the plant material to strip CBD and isolate it.

Hydrocarbon extraction is an efficient, low-cost, technique that gives out high CBD concentration. But it’s also flammable and could lead to residual solvents. There are also regulatory challenges and limitations that you need to check before conducting this method.

Olive Oil Extraction

Olive oil is another well-known solvent in CBD extraction for DIY practitioners. To use this method, you’ll need to grind the hemp to a fine powder and heat it inside olive oil. The heat will pull the bioactive compounds into the olive oil, ready to be used.

It’s a very simple method that you can easily do at home. However, it leads to lower CBD yield, as it is harder to separate other bioactive compounds and the CBD will have a shorter shelf life compared to other techniques.

Alternative CBD Extraction Methods

Aside from the four methods mentioned above, there are other alternative techniques that you can use: dry ice extraction and steam distillation.

In dry ice extraction, you’ll need to grind the hemp into dust before mixing it with dry ice in a container. The cannabinoids will freeze and become brittle, so it’s easily separated from the plant matter by sifting. It’s easier and can be done at home, but results in lower-quality products.

In steam distillation, the plant matter will be put into a distillation tank and then mixed with water and heat. The reaction will create a purely distilled full-spectrum CBD oil. It’s simple, but the technique may damage the plant. It’s also less efficient and requires a high volume of hemp to obtain a decent amount of CBD oil.

Choosing the Right Extraction Method

Choosing the right extraction method depends on your specific objective. DIY and at-home manufacturers may want a cost-effective way, but industrial-scale producers might require higher yields with better quality. Here are some factors to consider:

Product quality – How pure do you want your product to be? If you need high-quality products, you should go with CO2 extraction for the purest products.

Production scale – How much product are you planning to produce? If it’s for personal use, you can opt for simpler techniques. On the other hand, you’ll need more efficient techniques like CO2 or ethanol extractions for industrial-scale productions.

Budget – How much are you willing to spend as your initial capital? Extractions in industrial scale proportion will require a higher budget compared to techniques that you can do at home.

Conclusion

Extraction is an important step in determining your CBD product quality. Choosing the right extraction method means taking into account efficiency, product yield, product purity, and costs into consideration. Study each method carefully before selecting your technique to achieve the most suitable results.

If it’s just an at-home experiment, you can opt for simpler techniques. But if you’re looking for high-quality products with high purity, you can check out NuLeaf’s CO2-extracted CBD products instead!

CBD Extraction Methods: FAQs

What extraction method is best for CBD?

The best extraction method for CBD is CO2 extraction. This method is a selective extraction technique that results in the highest purity of CBD. Although it’s expensive and slower, it creates the best end product in terms of quality.

What solvents are used for CBD extraction?

Common solvents that are used for CBD extraction are CO2, ethanol, hydrocarbon, and olive oil. Each has its characteristics, which determine its efficiency, cost, and purity.

How do I know which solvent to use for extraction?

Choose the right solvent based on your needs. Determine your priority, whether it’s cost, yield, purity, or efficiency. Cross-reference your requirements with the pros and cons we’ve listed on this list and make your decision.

You may have heard of the endocannabinoid system in our body. But are you familiar with 2-Arachidonoylglycerol or, for short, 2-AG? This endocannabinoid is the most abundant in our body and has a significant role in maintaining the balance of our endocannabinoid system.

They will bind cannabinoid receptors in the central and peripheral nervous system, which are CB1 and CB2. They’re involved in physiological functions, including forms of neuroplasticity or the ability of neural networks to grow and reorganize.

It was first discovered in 1995 and has become the most extensively studied monoacylglycerol.

In this blog post, let’s find out how this substance is synthesized and its importance to our health.

Discovery and Historical Context

The study of the endocannabinoid system was first focused on endogenous cannabinoids and their effects, which then gave way to the exploration of a newly discovered receptor system – the endocannabinoid system.

Cannabinoid receptors were then characterized by Devane et al., who also isolated the first endocannabinoid, arachidonoyl ethanolamide or anandamide. After that, Raphael Mechoulam and his student, Ben-Shabat, discovered the second endocannabinoid known as 2-AG in 1995.

Professor Mechoulam and his team are considered the founders of cannabinoid and endocannabinoid research. Not only were they able to identify 2-AG, but they were also the ones who discovered the structure of plant-derived THC. All these findings make up our current knowledge of how the endocannabinoid system works. 2-AG binds to the CB1 and CB2 receptors, similarly to how THC (tetrahydrocannabinol) and CBD (cannabidiol) bind to these receptors. It will then signal the endocannabinoid system to react accordingly.

While THC and CBD are exogenous and need to be consumed, 2-AG can be synthesized by our body, hence the name endocannabinoid.

Chemical Nature and Synthesis of 2-AG

Chemical Composition

Regarding its chemical composition, 2-AG’s biochemistry is classified as an ester formed from the fatty acid omega-6-arachidonic and glycerol with the molecular formula C23H38O4.

Synthesis Process

There are two main pathways to 2-AG’s biosynthesis: signaling and metabolic pathways. The signaling pathway starts from phosphatidylinositol-4,5-bisphosphate or PIP2, while the metabolic pathway uses arachidonic acid and glycerol.

PIP2 will be converted by phospholipase C, diacylglycerol (DAG), and inositol-1,4,5-triphosphate. The metabolic pathway involves the hydrolysis of triglycerides by hormone-sensitive lipase.

The two pathways will converge and further be processed by diacylglycerol lipase (DAGL) to finally generate 2-AG and a fatty acid.

Comparison with Other Endocannabinoids

There are two major endocannabinoids in our body, which are 2-AG and anandamide. Anandamide was the first to be discovered and thus was more extensively studied. It turns out that 2-AG is more abundant and present in higher concentrations in the brain.

Both bind to cannabinoid receptors, but anandamide acts only as a partial agonist, while 2-AG is a full agonist for CB1 and CB2. A partial agonist means that it triggers a response that is lower than a full agonist.

Another difference is that 2-AG is very selective and binds only to cannabinoid receptors, while anandamide also interacts with others, such as vanilloid receptors.

Lastly, 2-AG is more active in the adult central nervous system as a neuromodulator. At the same time, anandamide is active during development as a growth factor and as a stress-responsive modulator during adult life.

Biological Functions of 2-AG

Physiological Roles

2-AG has been indicated to be a signal mediator that keeps brain homeostasis with its anti-inflammatory and neuroprotective effects when it goes through the hydrolysis process by MAGL. It has also been shown to have a prominent role in regulating anxiety and stress disorders by binding to the CB1 receptors and affecting stress-related hormones.

Moreover, 2-AG is suggested to have a role in maintaining energy balance in humans by regulating ghrelin levels and stimulating satiety.

Impact on Neurotransmitter Release

Another biological function of 2-AG is as a key regulator of neurotransmitter release. 2-AG induces the inhibition of neurotransmitter release by acting retrogradely onto CB1 receptors. This means that 2-AG mediates various forms of long and short-term plasticity.

Degradation and Metabolic Pathways

2-AG degradation involves multiple enzymes, which will decrease 2-AG levels and signaling. The most dominant pathway for 2-AG degradation is through hydrolysis of the ester bond into the arachidonic acid and glycerol.

The enzyme responsible for this degradation is mostly monoacylglycerol lipase (MAGL), but there are also hydrolases (ABHD12 and ABHD6), cyclooxygenase, and lipoxygenase.

Medical Implications and Research

Potential Therapeutic Uses

Based on 2-AG’s biological functions, there are many potential therapeutic uses for the endocannabinoid:

  • Seizures: 2-AG suppresses seizures through interaction with the CB1 receptor.
  • Neurodegenerative diseases: 2-AG is shown to be neuroprotective and can help with neurodegenerative diseases such as Parkinson’s disease.
  • Psychiatric illnesses: 2-AG, along with anandamide, has a role in modulating anxiety and depressive behaviors.
  • Appetite suppressants: 2-AG may be used to suppress appetite by regulating ghrelin levels and stimulating satiety.

Research Developments

As the endocannabinoid study is relatively new, you can expect more findings regarding 2-AG, such as its role in suppressing epileptic seizures. Animal studies found that 2-AG suppresses excessive excitability of the object’s neural circuits, thus protecting the brain from seizures.

Another recent finding is its presence in human breast milk. Both 2-AG and anandamide are found in breast milk, with 2-AG levels at much higher levels than anandamide. It was also found that women with higher BMI will have more 2-AG and that there’s a higher concentration during the day.

The Future of 2-AG Research

Since its discovery, we’ve managed to determine the characterization of 2-AG in the endocannabinoid system, how it’s synthesized, and its degradation. Seeing as it has plenty of potential in regulating our brain function, further clinical studies are still needed in terms of understanding its effects on our health and how to best utilize it.

For example, although 2-AG was found in human breast milk, its specific role in infant health remains unidentifiable.

Conclusion

2-AG is the most abundant form of endocannabinoid in our brain that acts as the natural ligand for cannabinoid receptors. It has potential for future medical applications, such as seizures, neurodegenerative diseases, psychiatric illnesses, and appetite suppressants.

Aside from endocannabinoids, another way to balance your endocannabinoid system is through cannabinoids.

2-AG FAQs

How does 2-AG differ from THC and CBD in its effects on the body?

The primary role of 2-AG is to maintain homeostasis or balance in our body, while cannabinoids such as THC and CBD are external sources used for therapeutic properties. 2-AG is produced in “as-needed-basis” naturally, while we can tailor the potency of THC and CBD to produce a certain effect.

What are the potential therapeutic benefits of 2-AG?

2-AG can potentially be beneficial for seizures, as appetite suppressants, to combat neurodegenerative diseases, and to help with psychiatric illnesses.

How is 2-AG involved in regulating bodily functions like pain and stress?

2-AG regulates several bodily functions by binding to the cannabinoid receptors, affecting stress-related hormones and inducing analgesic effects that reduce pain and stress.

What are the challenges in researching and utilizing 2-AG in medicine?

The field of endocannabinoid systems is relatively new, lacks depth, and is involved in an extensive network of bodily functions. It might be difficult to pinpoint its efficacy for certain therapeutic benefits. There are also hundreds of mediators that are chemically related to the endocannabinoids, making it difficult to target.

Cannabidiol, or CBD, has been gaining popularity in recent years. With a myriad of potential benefits* and forms, CBD products have become more accessible than ever before.

Despite its popularity, studies on CBD and its effects on our body are still relatively new. One particular topic that’s been going around is whether CBD can damage liver health when consumed in high dosages.

So, is CBD bad for your liver? Let’s find out if that’s true and how you can consume CBD safely.

Understanding CBD and Liver Health

Cannabidiol, or CBD, is one of the many cannabinoids in cannabis plants that can be derived from hemp plants or manufactured in a laboratory. Unlike THC, CBD is considered non-psychoactive and typically doesn’t cause a high when consumed, however this may not be the case for all users, as some may experience it differently*.

You can consume CBD in numerous forms, from CBD oil tinctures to topical products or gummies.

Like many other compounds we consume, cannabidiol will be metabolized by the liver. During this process, there’s a particular concern regarding hepatotoxicity, which can lead to liver toxicity.

There’s also a risk of drug interaction when CBD is taken with other medication, increasing the possibility of side effects. That’s why it’s important to consult a medical professional before you decide to consume CBD.

FDA Warnings and Clinical Studies

The FDA (Food and Drug Administration) has recently issued a warning on the consumption of CBD and liver injury, As mentioned on their page, this is due to research on applying a CBD drug called Epidiolex in mice.

It was found that consumption of the drug resulted in increased liver enzyme levels and, consequently, liver injury. However, complications mostly arise from drug interaction when CBD is consumed in high doses or with other medicines.

FDA mentioned that the risk can be managed when CBD is taken under medical supervision, in normal doses, and according to the guidelines of FDA-approved labeling. It is likely you will be safe if you take the appropriate amount of CBD, however, how your body reacts to it may differ from others.

Another study supported this statement, where normal doses of over-the-counter CBD products were shown to be potentially more tolerated without any signs of liver injury.

Research Findings: The Impact of CBD on the Liver

A laboratory study on CBD and hepatotoxicity using mice was done using high doses. The doses used for acute toxicity were 246 mg/kg, 738 mg/kg, and 2460 mg/kg. Ultimately, it was found that the highest dose exhibited hepatotoxicity and increased liver enzymes – ALT and AST.

On the other hand, another study concluded conflicting results. This particular study only used 5 mg/kg body weight, which is far below the concentration used in the previous study. This level of CBD administration was found to potentially assist the mice with their general wellness and support a calming effect on them.

CBD Dosage and Liver Safety

As you can see, when it comes to liver safety in CBD consumption, it’s all about dosage. Studies mentioned have demonstrated that extreme doses may lead to elevated liver enzymes and liver injury, while recommended doses may not have adverse effects.

It’s important to know that the high doses used in the study are almost impossible to reach with the typical use of CBD. For example, let’s say there’s a 10-mL bottle of CBD oil with 1,000 mg of CBD. If you weigh 70 kg, to reach the aforementioned dose of 2460 mg/kg, you’ll need 172,200 mg of CBD. That means you will be consuming over 172 bottles of the 10-mL bottle of CBD oil.

To be safe, follow the instructions provided on the packaging or consult a professional. Studies also show that doses up to 1,500 mg/day are well tolerated, so you might want to aim below that.

Potential Benefits of CBD for Liver Conditions

Extreme doses of CBD may be harmful to your liver, but CBD has potential positive effects on the liver.

By looking at these facts, finding the balance between the potential benefits* and risks of CBD is important. It is recommended you speak to your doctor to determine the appropriate treatment for your condition. Only use the correct dosage of CBD to avoid the potential harmful effects.

Conclusion

The FDA has released a warning regarding CBD consumption and liver injury due to a recent animal study. However, it’s important to note that these detrimental effects were observed in extremely high doses. Other studies have found that CBD may have potential wellness benefits*.

Nevertheless, due to the novel nature of CBD and its usage, further studies are still needed, and you should consult your healthcare providers before consuming any supplements.

The quality of your CBD products should also be a priority. Go for trusted brands such as NuLeaf Naturals that provide premium-grade CBD products in innovative forms. From CBD oil to drink mix and balm, we’re ready to support your overall wellness*.

CBD and the Liver: Frequently Asked Questions

Will CBD cause liver damage?

CBD could potentially cause liver damage when taken in higher doses than recommended without medical supervision. But if you consume CBD within the recommended doses, there’s little evidence that it could disrupt your liver function.

What is the safe dosage of CBD for liver health?

According to studies, high doses of CBD, up to 1,500 mg/day, are well tolerated in humans. To be sure, you can also refer to the recommended dosage on the labeling or consult a medical professional if needed.

Can CBD be used alongside liver medication?

Using CBD with other drugs is not recommended because it can interact and compete or interfere when they’re being broken down by the enzymes in the liver. The medication you’re consuming may not work or have an increased risk of side effects. Consult your physician before taking CBD if you’re currently taking prescribed medications.

Does CBD Oil Increase Liver Enzymes?

CBD may raise your liver enzymes, but it’s not potentially harmful as long as you consume it based on the recommended level. It can be dangerous when you consume high doses of the compound which could potentially lead to issues with your liver. That’s why you need to check the labeling of CBD products or consult a medical professional if unsure.

*This statement has not been evaluated by the Food and Drug Administration (FDA). NuLeaf products are not intended to diagnose, treat, cure, or prevent any disease.

If you’ve been hearing all about the cannabinoid CBD recently, you’re not alone. CBD has taken the world by storm and, since its legalization in numerous countries, has exploded in popularity.

However, rapid growth also comes with some risks. Without proper quality controls or a standard for CBD products, low-quality products can do more harm than good, so third-party lab testing is more crucial now than ever. It isn’t a “nice-to-have,” it is a “must-have”!

In this blog post, we’ll examine third-party lab testing and why it is so important in the ever-growing CBD industry.

What is CBD Lab Testing?

Although the FDA (Food and Drug Administration) regulates delta-9 THC for medical use, they do not regulate CBD products. Because of the lack of regulation, many unscrupulous manufacturers can jump on the CBD bandwagon and produce inferior CBD products that don’t measure up to quality controls or contain contaminants.

They can then pass them off as legitimate products despite no control over the purity, other ingredients, or potency. These products can not only be fraudulently labeled but also be downright dangerous to consume.

That’s where third-party lab testing comes in. CBD testing involves using a neutral, independent laboratory with no affiliation to the manufacturer. The third-party lab will conduct a series of tests for the CBD products’ purity, potency, and overall quality.

How CBD Lab Testing Works

A sample of each type of CBD product, whether it is CBD oils, topicals, edibles, or supplements, is sent to the third-party lab. The lab then conducts tests on the samples to determine the quality of the product, and in particular, cannabinoid profiling.

Cannabinoid profiling not only tests for the CBD levels but also for the THC levels, if any. Legally, a CBD product can only be sold if it has less than 0.3% THC, according to the 2018 Farm Bill.

The lab also does other tests to check for chemical contaminants like pesticides, solvents, and heavy metals. Harmful microorganisms such as mold, bacteria, and yeast are also tested to ensure the CBD product is safe for consumption.

After all the samples are analyzed, each product is given a Certificate of Analysis (COA) to reflect the test results. All CBD manufacturers should have a COA publicly available for all their products. This transparency allows customers to verify the quality of the product and establish trust with the brand.

Understanding COAs

Depending on the third-party lab you use, a COA can vary slightly, but most will contain information like:

Product name – The exact product being tested

Name of the lab – The third-party lab

Batch or lot number – A unique identifier assigned to the specific production batch of the product.

Cannabinoid profile – The exact contents of each product and its potency. As mentioned earlier, it is particularly important to measure the concentrations of each cannabinoid. A COA will also clearly state the levels of THC to ensure that it complies with the 0.3% limit. In addition, the profile will also show the presence of other cannabinoids, such as CBG and CBN.

Terpene profile – This showcases the terpenes present

Heavy metals and residual solvents – The lab will test for the presence of heavy metals and solvents.

Microbial analysis – This tests for contaminants such as mold, fungi, or bacteria in the product.

Pesticide analysis will show any pesticide residue present in the sample, which kind, and the lower detection limit.

Lab technicians’ signature – A COA must be signed off by the third-party lab.

Are you interested in learning more about COAs? Learn more about how to read a Certificate of Analysis here.

cbd being tested in a lab

Benefits of Third-Party Lab Tested CBD

Full Cannabinoid Breakdown

CBD that has a COA will have a complete cannabinoid profile. That way, you’ll know your CBD product is as potent as it claims. In addition, the CBD product is guaranteed to have a maximum of 0.3% THC, which is the legal limit.

This is especially important if you are administering CBD to pets, as their tolerance for THC is much lower than a healthy adult’s.

Identification of Contaminants

Products with a COA are guaranteed to have zero to acceptable levels of contaminants like pesticides, heavy metals, residual solvents, mold, and bacteria.

Establishes Consumer Trust

Regular CBD users know to look for the COA when purchasing products. Consumers are far more likely to buy a product with a COA, which means a third-party lab has thoroughly tested it for safety, potency, and overall quality.

A vast majority of CBD manufacturers have COAs for all their products, and most consumers wouldn’t even dream of purchasing hemp products that haven’t been tested.

It Reduces Liability

Suppose a product has been tested by a third-party lab and deemed safe. In that case, the manufacturer cannot be held accountable for any unsafe levels of contaminants or improper labeling of ingredients.

How to Choose a Third-Party Lab

When choosing a third-party lab to test CBD products, manufacturers should consider the following:

Technology – What type of technology does the testing laboratory use, is it outdated, or state-of-the-art?

Experience – How experienced are the lab and its employees?

Testing Record – How much testing has the lab done, have they used testing services, and what is its success rate?

Certifications – Is the lab accredited with GMP (Good Manufacturing Practices) or other certifications?

Final Thoughts

The explosive growth in the popularity of CBD products is phenomenal, but because it is relatively new, it remains unregulated by a governing body. This can lead to inferior products that are unsafe for consumption, potentially giving you unwanted side effects that are detrimental to health.

That’s why third-party lab testing is so important. It isn’t mandatory yet, but consumers are already aware enough to only buy products that come with a COA.

At NuLeaf Naturals, all our high-quality products come with COAs on every batch, so our customers know exactly what’s in their specific product. You simply key in the batch number on our Lab Reports page to find the specific COA for the product.

For us here in Colorado, Fall doesn’t last very long. It’s like you blink, and suddenly, summer has turned into winter! The cold usually hits around Halloween, and we all scramble to get our flu shots, stock up on cold meds, and hunker down for the winter months.

As winter approaches, so does the cold and flu season, making focusing on health and wellness even more important to ward off bacteria and viruses and reduce the likelihood of getting sick.

In this blog post, we’ll look at why keeping healthy in winter is important and share some tips on remaining full of vitality as the cold weather hits.

The Importance of Healthy Habits During Winter

As the temperature drops, our immune systems can be compromised as our body works hard at keeping warm. Seasonal viruses tend to be more prevalent in cold weather, increasing your risk of contracting a respiratory infection.

In addition, cold air also tends to be dry, which dries out the membranes in the respiratory system, making it easier for viruses to find their way in. Colder temperatures mean you might spend more time indoors instead of out and about, and the shorter daylight hours don’t help.

Winter can even lead to a decline in mental health and cause some winter blues or a condition called Seasonal Affective Disorder (SAD). The reduced exposure to the sun also means you might lack vitamin D, which is essential in supporting immune function.

To stay healthy, it’s important to understand the challenges posed by the impending winter and be more conscious of our lifestyle choices to prevent illness. Here are some winter health tips for the upcoming 2024 season to help you do just that!

10 Winter Health Tips for 2024

Stay Hydrated

Cold weather causes dehydration, so remember to drink plenty of fluids. The recommended daily amount is 2.7 liters for women and 3.7 liters for men. This means women should drink 8 glasses, and men should drink 12.

Moisturize

Winter can dry out your skin and lips. Make sure to slather on lip balm and moisturizer on the dry areas to ensure that your skin and lips don’t flake or crack.

If you can, try using natural ingredients like shea butter or coconut oil, especially on your face. The harsh chemicals in commercial products often do more harm than good.

“Stock” Up on Soups and Stews

Soups and stews are excellent winter comfort foods, so stock up! Chicken soup, beef stews, minestrone, and shrimp or chicken gumbo are all low-calorie stews that are great for cold weather.

Some stews take longer to make than others, so you can make up a big batch and freeze or refrigerate them to enjoy a hearty bowl of hot soup anytime.

Stay Active

Physical activity continues to be important despite the cold temperatures making it difficult. Even a light workout will increase your body temperature, raise your heart rate, and improve blood flow and energy levels.

If you’re exercising outdoors, be sure to layer up enough. Be careful when you’ve finished your exercise, and try to stay warm. The evaporative cooling from wet clothes can cause you to feel even colder and put you at risk of falling ill.

If heading outdoors is not possible, try home workouts like a one-hour power yoga session or some calisthenics as part of your exercise routine. You can also invest in an exercise bike or treadmill to regularly get a good cardio workout in the comfort and warmth of your own home.

Layer Up

If you’re planning to get outdoors, be sure to layer up with warm clothing. Overexposure to cold can result in several nasty conditions like hypothermia, frostbite, or cardiovascular stress. Check the temperature and ensure you have enough layers to stay warm.

If you just moved to a cold climate, a good way to layer the top is a base, a thick fleece, and an outer shell to protect yourself from the wind. You’ll probably be able to get away with jeans for the bottom unless it’s freezing, then ski pants it is!

Don’t forget a beanie and some gloves. Your head loses about 30% of body heat, so protect your noggin!

woman layering clothing for winter

Use a Humidifier

You can use a commercially available humidifier for your home to keep the air less dry, which will help with chapped lips, dry skin, and dehydration. Try to find an energy-efficient humidifier that is the appropriate size for the room you intend to use it in.

Also, note the maintenance cost and safety features like the automatic shut-off when the water runs out to prevent damage.

Get Plenty of Rest

The shorter days might mean you sleep longer, which isn’t necessarily bad! Resting more during winter is one of the best ways to boost your immune system and reduce the risk of illness.

You’ll have the perfect excuse for going to bed early and sleeping in the following day!

Take Supplements

Consider adding some supplements to your diet to help your body’s immune system out. The shortening days and more indoor time mean you might lack vitamin D so you can incorporate that into your routine.

Vitamin C is essential for the immune system and contains antioxidants crucial for your health, so you might want to take those as well, especially if you aren’t getting enough fruits and veggies.

You can also consider incorporating CBD into your routine for overall wellness*, as the cannabinoid will help maintain your body in a state of homeostasis or balance. CBD is available in many forms, like oil, capsules, or gummies.

Wash Your Hands Often

This is an all-around healthy habit, but in winter, we are more susceptible to germs and viruses, making good hygiene even more important. Use a hand sanitizer if you don’t want cold hands.

Visit the Doctor Immediately When You Get Sick

If you do fall sick, see a healthcare provider before it gets worse! Also, take the necessary steps to limit your contact with others to avoid passing the bug around.

Maintain Winter Wellness Naturally with NuLeaf Naturals CBD

Maintain wellness naturally* and incorporate NuLeaf CBD products in your daily routine. All our products are of the highest grade, with a full spectrum of cannabinoids and terpenes working together to create an entourage effect for optimal results.

Our products are made under the most stringent manufacturing standards in our Colorado facility. They are independently verified by third-party labs to ensure they are completely safe and free of pesticides, herbicides, mold, fungi, heavy metals, and mycotoxins.

Take charge of your winter wellness* with CBD from NuLeaf Naturals!

*This statement has not been evaluated by the Food and Drug Administration (FDA). NuLeaf products are not intended to diagnose, treat, cure, or prevent any disease.

Almost all cannabis lovers have heard of CBD (cannabidiol) and its famous cousin, THC (tetrahydrocannabinol), but what about endocannabinoids?

These naturally occurring cannabinoids are produced by our bodies as part of the complex Endocannabinoid System (ECS). This system is responsible for keeping our bodies in balance or homeostasis.

CBD and THC, on the other hand, aren’t produced naturally and have to be obtained through external sources like oils, topicals, tinctures, smoked flower, or edibles.

There are a few known endocannabinoids, but the most famous is anandamide. In this blog post, we’ll take a closer look at this helpful endocannabinoid that plays an essential role in optimizing many of our physiological processes.

Endocannabinoids: A Quick Intro

Our bodies are full of complex networks like the digestive system, central nervous system, respiratory system, and circulatory system. One of the lesser-known networks is the Endocannabinoid System (ECS), which is present in all mammals and some other animals.

As mentioned earlier, the ECS is partly responsible for many physical and mental processes, such as regulating mood, pain perception, appetite, sleep, and managing stress and anxiety.

Endocannabinoids are a critical part of the ECS, together with enzymes and receptors, all of which naturally occur in our bodies. Learn more about the endocannabinoid system.

What is Anandamide?

There are two naturally occurring endocannabinoids found in the human body: Anandamide and 2-arachidonoylglycerol (2-AG).

Anandamide has its name derived from the Sanskrit word “Ananda,” meaning bliss, hence its nickname, the “bliss molecule.” Anandamide can also be called AEA after its complete name (N-arachidonoylethanolamine).

When your body is out of balance, it will trigger the release of anandamide to restore it. The compound interacts with two endogenous cannabinoid receptors, the CB1 and CB2 receptors, to achieve balance and homeostasis in the body.

Once the anandamide has done its job, it is degraded by fatty acid amide hydrolase (FAAH). This regulation limits the effects of anandamide and controls its effects.

CBD (cannabidiol) slows the inhibition of anandamide by the FAAH and, hence, can prolong the effects of anandamide in the body, which tends to account for the relaxed, calm feelings that CBD is known for. However, research is still in its preliminary stages, and more clinical trials must be done to fully understand the effects of CBD.

anandamide chemical structure

Potential Benefits of Anandamide

Anti-Tumor

More than 20 years ago, anandamide was found to inhibit breast cancer cell growth. Anandamide was found to selectively slow the growth of human breast cancer cells in vitro and restrict cancer cell lines known to express estrogen.

In addition, the study found that anandamide can slow down cell growth, and this might happen because it reduces the making of prolactin receptors, which are needed for the hormone’s action. This, in turn, leads to a decrease in the product of the brca1 gene, which is a cancer marker.

Cardiovascular Wellness

Cannabinoids have long been known to have hypotensive effects. One study found a correlation between manipulating the ECS to control blood pressure, heart disease, and hypertension.

It is also suggested that new therapies involving anandamide could significantly improve the quality of cardiovascular patients. Some applications modulated by the ECS are currently in preclinical and clinical stages.

Appetite Stimulation

A 2001 study done on rats found that administering anandamide caused a slight improvement in appetite. This could have potential uses for cancer patients undergoing chemotherapy or patients with liver or kidney disease.

Anti-Nausea

Some studies found that cannabinoids can be used to reduce nausea and vomiting and also potentially benefit cancer patients who are undergoing chemo.

Pain Management

Because of the effect that the ECS has on the CB1 and CB2 receptors, the use of cannabinoids might be helpful in altering pain perception. One such study found that rats that were administered anandamide showed analgesic effects and reduced responses to inflammatory triggers.

Anti-Inflammatory

A recent study done in 2020 found that anandamide has unique anti-inflammatory properties that could reduce inflammation in smooth muscle cells. The compound showed that it could potentially reduce the movement of immune cells to inflamed areas.

While all the research so far has proved promising, more research is needed into the potential benefits of anandamide before any hard and fast claims can be set in stone.

CBD and Anandamide

CBD works not by interacting with the CB1 and CB2 receptors but by other aspects of the body, such as other neurotransmitters like serotonin and dopamine, as well as the FAAH enzyme.

The FAAH enzyme degrades anandamide, and with CBD inhibiting its effectiveness, it may increase the level of anandamide in the body.

Final Thoughts

Anandamide is a lesser-known compound of the endocannabinoid system but no less important. Its use has been widely known to improve overall well-being, although research is in its infant stages.

 

The variety of CBD products has been expanding rapidly to meet skyrocketing demand. CBD is now the star ingredient in everything from gummies and softgels to tinctures, drink mixes, topicals, and more.

This abundance of options can lead some consumers to feel overwhelmed and unable to decide. Fret not; we are here to help! NuLeaf Naturals is excited to share our newly-released CBD starter kits for beginners: our CBD Oil Starter Kit and CBD Softgel Starter Kit!

The Big Deal About Bundles

Variety is the spice of life, and our CBD bundles allow you to sample several CBD products before choosing your favorite. Whether you want to use a topical balm, CBD oil, or munch on some gummies, going with a bundle will help you pick what’s best for you.

This can be especially helpful for CBD newbies who are unsure which CBD product is right for them. To sweeten the deal, CBD bundles are more affordable than if you were to purchase each product separately!

If you’ve got a friend or family member that appreciates CBD, bundles make a great gift! Few things say “I care” more than a CBD bundle that will benefit their overall wellness*.

What’s in a CBD Starter Kit?

At NuLeaf Naturals, we offer two CBD starter kits: one with our flagship CBD oil and another with CBD softgels. In addition, each starter kit also contains gummies and a topical cream.

If you don’t want oil or softgels, learn the differences or try them both!

CBD Oil

Our award-winning CBD oil is the star of our CBD Oil Wellness Bundle, which also comes with gummies and balm.

With a potency of 60 mg/mL, the full-spectrum NuLeaf CBD oil is made with extract of the whole hemp plant grown in Colorado and organic virgin hemp seed oil. Full spectrum means that in addition to CBD, they also contain secondary cannabinoids like CBC, CBG, and CBN, giving you the full benefit of the entourage effect!

CBD Softgels

Our CBD softgels are precisely dosed at 15 mg per capsule and are the star of the show in our CBD Softgel Wellness Bundle, which also contains balm and gummies.

Like our oils, the softgels are made with organic hemp plants from Colorado under the strictest manufacturing standards.

Unlike oils, which you will taste, softgels are tasteless and convenient on the go. We suggest two capsules daily for a start, then gradually increasing until you get the results you’re looking for.

CBD Gummies

You’ll love our CBD gummies if you’ve got a sweet tooth. With a precise dose of 15 mg per gummy, our NuLeaf CBD Gummies are made with organic ingredients and contain no artificial flavors or preservatives. The color comes from fruit juice!

Available in strawberry, orange, lemon, and blueberry, we recommend you start with two gummies daily if you’re new to CBD and adjust the dosage accordingly once your body adapts. Learn more about how to take CBD gummies.

CBD Balm

Our unscented, full-spectrum CBD balm is designed for targeted topical application. It has only two ingredients: organic shea butter and concentrated hemp extract. Soothe your skin with the natural ingredients in our CBD balm and feel the difference.

Great for Family and Friends

Do you know someone who uses CBD? Our new Wellness Bundles make great gifts for friends and family. And if you know someone who’s curious about CBD but is unsure where to start, a bundle makes a great gift to let them try different ways of administration to help them begin their CBD journey.

Your Trusted Source for All Things CBD

For years, NuLeaf Naturals has been a trusted source of high-quality, pure CBD products made under the strictest safety standards and lab-tested for purity.

Thousands of happy customers have given glowing reviews that speak wonders about the products we have lovingly crafted. You have one body; let us help you take care of it! Try our wellness bundles today and experience NuLeaf CBD in all the best ways!

*This statement has not been evaluated by the Food and Drug Administration (FDA). NuLeaf products are not intended to diagnose, treat, cure, or prevent any disease.

Now more than ever, CBD products are everywhere. Despite that, since the FDA hasn’t approved any CBD oil, the market is still very unregulated, leaving it open to low-quality and sometimes potentially hazardous CBD products.

That’s why we’ll tell you everything you need to know about how to find the best quality CBD oil to ensure you’re getting the best option.

Let’s get started!

Understanding CBD Oil

Before we dive in to determining CBD oil quality, let’s take a quick look at what CBD oil is.

What is It?

CBD is one of over a hundred cannabinoids in cannabis, alongside the more well-known THC (tetrahydrocannabinol), responsible for the “high” effects. Full-spectrum CBD (or cannabidiol) oil, a concentrated extract of CBD from the cannabis plant mixed with a carrier oil, such as MCT oil or hemp seed oil, has only a miniscule amount of THC.

How is it Made?

CBD oil is made by first extracting CBD and other cannabinoids from the cannabis plant to create a concentrated hemp extract. 

Once the CBD is extracted, it’s mixed with a carrier oil, like coconut or hemp seed oil, to create topical balms or tinctures.

High-Quality CBD Oil: Factors to Consider

To make an informed choice, keep these factors in mind when evaluating CBD oil:

Full Spectrum, Broad Spectrum, or CBD Isolate

Understanding the spectrum of CBD extracts is very important when choosing your product.

Full Spectrum CBD Oil

This type of CBD oil contains a wide range of cannabinoids, including CBD and trace amounts of THC (below 0.3%). Full-spectrum oil also includes terpenes and other natural compounds from the cannabis plant. Full spectrum products are often sought for their “entourage effect,” where the cannabinoids of the plant work together synergistically, affecting the endocannabinoid system and potentially enhancing the overall effect.

Broad Spectrum CBD Oil

Broad-spectrum CBD oil contains many of the same compounds as full spectrum, including CBG, CBN, terpenes, and flavonoids, but with one crucial difference: it has no detectable THC.

This option is perfect if you want the benefits* of multiple cannabinoids but want to avoid THC altogether.

CBD Isolate Oil

Isolate CBD is the purest form of CBD, containing 99% CBD with no other cannabinoids or compounds. CBD isolate is entirely THC-free and often chosen by CBD users who want to avoid any trace of THC in their CBD products and are looking for pure CBD.

Learn more about Full Spectrum vs. Broad Spectrum CBD.

Hemp Source

The source of the hemp used to produce CBD oil is very important. The best CBD oils are typically derived from USDA-certified organically grown hemp plants grown in clean, nutrient-rich soil without harmful pesticides, herbicides, or other chemicals. Most products in the USA use U.S.-grown hemp, usually grown in places like Colorado, where there’s a large hemp and cannabis industry. 

Extraction Method

Although there are multiple ways to extract CBD, some of the most popular extraction methods are:

  • CO2 Extraction: This method uses carbon dioxide under high pressure and low temperatures to extract all cannabinoids from the plant so they can be incorporated into CBD gummies, edibles, and oils. CO2 extraction is considered one of the cleanest and most efficient methods to produce high-quality CBD oil.
  • Solvent Extraction: Solvents like ethanol or butane are used to separate CBD from the plant material. While effective, this method requires another extraction process to remove any residual solvents that can negate CBD’s benefits*.
  • Olive Oil Extraction: Although not as common, in this method, cannabis plant material is heated and mixed with olive oil to extract CBD. Although it’s a simple and safe method, it’s not as popular because it produces a product with a lesser amount of CBD.

cbd oil extracted in lab

Potency

CBD oil potency is usually measured by checking the concentration of mg of CBD per milliliter. Determining the correct dose is crucial to fully enjoying CBD oil’s benefits*. Beginners often mistake high potency for better quality, which might not necessarily be the case. Still, it may be more cost-effective if you require a higher dose of CBD regularly to experience the effects of CBD.

Ingredients

High-quality CBD oil products should contain minimal ingredients. If you’re looking for purity, look for unflavored, organic CBD oils that use natural carrier oils, and avoid those with artificial additives or preservatives. Some products also contain essential oils with natural flavors to give you more flavor options with natural and organic ingredients.

Certificate of Analysis (COA) and Lab Testing

Reputable CBD brands provide third-party lab testing results, typically available in a Certificate of Analysis (COA). The COA should confirm the CBD content, verify the absence of harmful contaminants like heavy metals and pesticides, and validate that the THC content complies with legal limits.

How to Choose the Right CBD Oil Brand

Ready to pick up some CBD oil? Here’s what you need to keep in mind when you’re picking one:

GMP Certification

When it comes to selecting the best CBD products, GMP (Good Manufacturing Practices) certification is a crucial factor to consider. GMP certification indicates that a CBD company adheres to high-quality controls and manufacturing standards.

Look for trusted CBD brands that claim GMP compliance and provide evidence of third-party testing.

You can learn more about why GMP compliance matters in the CBD industry here.

Customer Reviews

Customer reviews are critical when you’re deciding which CBD products to buy.

At NuLeaf Naturals, we are proud to have accumulated over 25,000 customer reviews for our CBD oils, with an average rating of 4.9 out of 5 stars, letting you know our clients always get high-quality products.

Price

While price is a factor, it should not be the sole determinant when choosing a CBD oil brand. High-quality CBD products undergo rigorous testing, use premium ingredients, and adhere to GMP standards, which can make them slightly more expensive. Be cautious of significantly cheaper CBD products, as they may cut corners regarding quality and safety.

Learn more about where to buy CBD oil.

The Best Quality CBD Oil for Sale Online

Regarding the best quality CBD oil for sale online, there’s no better choice than NuLeaf Naturals. Here’s why:

  • GMP Certified Status: We adhere to the highest manufacturing standards to ensure product safety and consistency.
  • Customer Reviews: With over 25,000 reviews and a 4.9/5 star rating, you can trust our customers are satisfied with their purchase!
  • Quality Ingredients: We use 100% organic hemp, CO2 extraction methods, and natural carrier oils to produce premium CBD oils.

Ready to get high-quality CBD oil? Get NuLeaf Naturals CBD oil on our website today.

*This statement has not been evaluated by the Food and Drug Administration (FDA). NuLeaf products are not intended to diagnose, treat, cure, or prevent any disease.