A Scientific Review of the 5 Best Full Spectrum CBD Oils for Overall Wellness

In the pursuit of general well-being, full spectrum CBD oil has emerged as a popular option for natural wellness. The effectiveness of these oils is not defined by a single ingredient, but by the complex synergy of all compounds within the hemp plant. This guide provides a scientific review of the best full spectrum CBD oils, designed to help you make an informed decision for your wellness journey.

Key Takeaways

What Makes an Oil “Best”: The best full spectrum CBD oils contain a complete profile of cannabinoids and terpenes in a pure, organic carrier oil, delivering a powerful “entourage effect.”

• Top 5 Oils for 2025: NuLeaf Naturals offers the top 5 full spectrum oils, distinguished by their cannabinoid profiles and potency to target specific goals like daily balance, sleep, recovery, focus, and comprehensive support.*
• The Power of Synergy: Full spectrum oil is different from CBD isolate because the combined action of plant compounds creates what is known as the ‘entourage effect,’ which supports the overall benefits of the product.*
• Choosing Your Oil: Your primary wellness goal—be it better sleep, post-exercise recovery, or improved focus—is the most important factor in selecting the right cannabinoid profile for your needs.
• Quality and Purity: NuLeaf Naturals utilizes advanced CO2 extraction and organic virgin hemp seed oil to make sure the highest quality and purity, with all products verified by third-party lab tests.

What is Full Spectrum CBD Oil and Why is It Superior?

Full Spectrum CBD oil is a hemp extract that contains all the naturally occurring compounds from the cannabis plant. This includes Cannabidiol (CBD), the most well-known cannabinoid, along with over 100 other vital cannabinoids like Cannabichromene (CBC), Cannabigerol (CBG), and Cannabinol (CBN). It also contains a rich profile of terpenes, flavonoids, and essential oils that contribute to the oil’s efficacy and aroma.

Its potential comes from a principle known as the ‘entourage effect.’ This term describes the synergy where these diverse compounds work together. Each component complements the properties of the others, offering a different experience than products containing only isolated CBD.

This whole-plant approach allows your body to interact with the full spectrum of compounds found in the hemp extract. The cannabinoids engage with your body’s endocannabinoid system (ECS), which is a vast network of receptors. Providing a full spectrum of compounds can help support general wellness routines by promoting healthy sleep cycles and the management of day-to-day stresses.*

You can explore the key differences in our guide: What’s the Difference Between Full Spectrum CBD Oil and Isolate?

The Top 5 Full Spectrum Oils for 2025

The following five oils from NuLeaf Naturals are ranked as the best for 2025. Each is formulated in a base of organic virgin hemp seed oil using advanced CO2 extraction, making sure a pure and potent product. They are differentiated by their unique cannabinoid profiles to provide targeted, effective support for your specific wellness objectives.

1. Best Overall Wellness – Full Spectrum Hemp CBD Oil (60mg/mL)

Factual Proposition: NuLeaf Naturals’ flagship CBD oil is the best choice for foundational, daily wellness. It contains a high concentration of CBD (60mg per mL) alongside the full range of synergistic cannabinoids and terpenes.

This formulation is engineered to provide comprehensive support for the endocannabinoid system, promoting a sense of balance and well-being. Its single ingredient, Full Spectrum Hemp Extract in Organic Virgin Hemp Seed Oil, makes it the purest and most fundamental option for those new to CBD or seeking consistent, daily support. This high-quality CBD oil is ideal for managing everyday stress and supporting overall health.

Learn more about the CBD Oil (60mg/mL)

2. Best for Sleep and Relaxation – Full Spectrum CBN Oil (60mg/mL)

Factual Proposition: This specialized full-spectrum CBN oil is formulated to support deep relaxation and healthy sleep cycles.* CBN (Cannabinol) is a non-intoxicating cannabinoid that forms naturally as THC oxidizes and ages. Unlike single-compound extracts, this formula retains a range of minor cannabinoids and terpenes that work synergistically to improve CBN’s calming effects — a phenomenon known as the entourage effect.*

Each serving delivers the combination of 30mg of CBN and 4mg of total other cannabinoids per serving, designed to calm the body and mind, preparing you for a restorative night’s sleep without the grogginess sometimes associated with conventional sleep aids.*

Learn more about the CBN Oil (60mg/mL)

3. Best for Recovery – Full Spectrum CBC Oil (60mg/mL)

Engineered for physical wellness, his full-spectrum CBC oil is formulated to support post-exercise recovery and overall wellness.* Cannabichromene (CBC) is a non-intoxicating cannabinoid known for its potential to support healthy inflammatory responses and promote balance after physical activity.*

This formula contains The combination of 30mg of CBC per serving and 4mg of total other cannabinoids per serving helps support a healthy response to stress, allowing for sustained concentration.*

Each serving delivers a potent dose of CBC to help support your body’s recovery and return to homeostasis without the use of synthetic ingredients or stimulants.* This oil offers general wellness support for athletes and fitness users.*

Learn more about the CBC Oil (60mg/mL)

4. Best for Focus and Energy – Full Spectrum CBG Oil (60mg/mL)

CBG, often called the ‘mother of all cannabinoids,’ is the precursor from which other cannabinoids are synthesized. It is an excellent choice for daytime use, helping to support focus.* The combination of 30mg of CBG per serving and 4mg of total other cannabinoids per serving helps support a healthy response to stress, allowing for sustained concentration.*

Learn more about the CBG Oil (60mg/mL)

5. Best for Comprehensive Support – Multicannabinoid Oil

This is a complex full spectrum oil, containing a powerful 1:1:1:1 ratio of CBD, CBG, CBC, and CBN. It is designed to provide a robust entourage effect by incorporating five different cannabinoids (including trace THC) in a high-potency formula. This blend offers multifaceted support by combining cannabinoids associated with balance, focus, recovery from exercise, and relaxation.*

Learn more about the Multicannabinoid Oil (60mg/mL.)

How to Choose the Right Full Spectrum Oil for You?

Selecting the best full spectrum oil from our top 5 list is straightforward when you align the product with your primary wellness objective. Consider what aspect of your health you most want to support. Are you looking to establish a baseline of daily wellness, or do you have a more specific goal like improving sleep or improving workout recovery?

Use the table below as a simple guide to match your needs with the ideal cannabinoid profile. This table helps you select the best full spectrum oil from our top 5 list based on your primary wellness objective.

Frequently Asked Questions about Full Spectrum CBD

How is full spectrum oil different from an isolate?

Full spectrum oil contains a wide range of cannabinoids and terpenes that work together to create the ‘entourage effect.’ An isolate contains only CBD and lacks these other complementary compounds, offering a different kind of experience.

Can you fail a drug test from full spectrum CBD oil?

It is possible. Full spectrum CBD oil contains trace amounts of THC (less than 0.3% as federally mandated). While this amount is not intoxicating and is legal, it could potentially accumulate in the body over time and be detected on a highly sensitive drug screening. Users who are subject to regular drug testing should consider a THC-Free broad spectrum product.

What is organic virgin hemp seed oil?

Definitive Answer: Organic virgin hemp seed oil is a cold-pressed oil derived from hemp seeds. It serves as a pure, nutrient-rich carrier oil that is high in Omega-3 and Omega-6 fatty acids. This carrier oil is not only beneficial on its own but also helps the body absorb the fat-soluble cannabinoids more effectively.

You can read more in our Guide to Hemp Oil.

How much full spectrum CBD oil should I take?

It is possible. Full spectrum CBD oil contains trace amounts of THC (less than 0.3% as federally mandated). While this amount is not intoxicating and is legal, it could potentially accumulate in the body over time and be detected on a highly sensitive drug screening. Users who are subject to regular drug testing should consider a THC-Free broad spectrum product.

Is full spectrum CBD oil legal?

Yes. Thanks to the 2018 Farm Bill, hemp-derived CBD products are federally legal in the United States as long as they contain less than 0.3% THC. All NuLeaf Naturals products are compliant with this regulation and are third-party lab tested to verify their cannabinoid content.

How do I take full spectrum CBD oil?

Full spectrum CBD oil is taken sublingually, which means you place the drops directly under your tongue. Hold the oil there for 30-60 seconds before swallowing. This method allows the cannabinoids to be absorbed directly into the bloodstream through the mucous membranes, offering faster and more efficient absorption than simply swallowing it.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.“