CBD vs. CBN vs. CBG: An In-Depth Comparison of Their Properties

The world of hemp wellness is much bigger than just CBD. Other cannabinoids, like CBN and CBG, offer their own unique properties for a well-rounded routine. While they all come from the same plant, their effects and primary uses are distinctly different.

This guide will compare these three cannabinoids, helping you understand how CBN may support relaxation and sleep cycle*, while CBD and CBG may promote foundational wellness and recovery from exercise*. Explore their profiles to find the right fit for your personal wellness goals.

Key Takeaways

• Primary Differences: The core distinction between CBD, CBN, and CBG is their primary supported use. CBN is specifically targeted for promoting relaxation and a healthy sleep cycle*. CBD and CBG are foundational cannabinoids that support overall wellness and recovery from daily stressors and exercise*.
• Scientific Origin: CBG is known as the “mother” or “stem cell” cannabinoid, as it is the chemical precursor from which others like CBD are derived. In contrast, CBN is a metabolite, formed from the natural degradation and aging process of THC.
• Body Interaction: Each cannabinoid interacts uniquely with the body’s Endocannabinoid System (ECS). CBG binds directly to both CB1 and CB2 receptors, CBD works indirectly to promote holistic balance, and CBN has an affinity for the CB1 receptor in a way that supports rest and relaxation*
• The Entourage Effect: You do not have to choose just one. The “entourage effect” is a scientific theory suggesting that cannabinoids, terpenes, and flavonoids work better together. Combining CBD, CBN, and CBG provides synergistic benefits for a more comprehensive approach to wellness*.

A Deeper Look: The Endocannabinoid System (ECS)

To understand how cannabinoids work, one must first understand the system they interact with: the Endocannabinoid System (ECS). Discovered in the early 1990s, the ECS is a complex and vital cell-signaling network that supports the body’s regulatory functions. Its primary function is to maintain homeostasis—a state of stable internal balance, despite fluctuations in the external environment. The ECS influences a vast range of physiological processes.*

The ECS consists of three core components:

1. Endocannabinoids: These are cannabinoid-like molecules produced naturally by your body on demand. The two key endocannabinoids identified so far are anandamide (often called the “bliss molecule”) and 2-arachidonoylglycerol (2-AG). They travel through the body and bind to cannabinoid receptors to signal that the ECS needs to take action.
2. Cannabinoid Receptors: These receptors are found on the surface of cells throughout the body. The ECS has two primary receptors:
   • CB1 Receptors: These are most abundant in the central nervous system (the brain and spinal cord) and are associated with regulating mood, memory, and our response to stress
   • CB2 Receptors: These are primarily located in the peripheral nervous system, especially in immune cells, and play a role in the body’s immune responses.
3. Metabolic Enzymes: These enzymes are responsible for breaking down endocannabinoids once they have served their purpose. The primary enzymes are FAAH, which breaks down anandamide, and MAGL, which breaks down 2-AG.

Phytocannabinoids—the cannabinoids derived from the hemp plant like CBD, CBN, and CBG—can interact with this system, primarily by influencing the cannabinoid receptors and metabolic enzymes. This interaction is how they help support the body’s natural ability to maintain balance and health*

Understanding the Cannabinoids: Individual Profiles

Before a direct comparison, it’s essential to understand each cannabinoid on its own terms.

CBG (Cannabigerol): The “Mother” Cannabinoid

CBG is often referred to as the “mother” or “stem cell” of all cannabinoids because it is the chemical precursor to many others. In a young hemp plant, enzymes convert cannabigerolic acid (CBGA) into the acidic forms of the three main cannabinoid lines: THCA (tetrahydrocannabinolic acid), CBDA (cannabidiolic acid), and CBCA (cannabichromenic acid). From there, through a process called decarboxylation (heating), these compounds become the cannabinoids we know, like THC and CBD.

• Interaction with the ECS: CBG interacts directly with both CB1 and CB2 receptors. This direct action allows it to provide targeted, non-intoxicating support for the ECS.
• Why It’s Rare: Because CBGA is immediately converted into other cannabinoids as the plant matures, most hemp strains contain very low levels of CBG (often less than 1%). This rarity makes CBG extracts more difficult and expensive to produce. NuLeaf Naturals utilizes proprietary genetics and advanced cultivation programs to grow hemp naturally high in CBG.
• Primary Supported Uses: CBG may potentially support wellness and recovery from exercise*. Users often seek it out to help maintain mood balance and focus*.

CBD (Cannabidiol): The Foundational Balancer

CBD is the most well-known and researched non-intoxicating cannabinoid, celebrated for its broad-ranging wellness applications. Unlike CBG, it is found in abundance in mature hemp plants.

• Interaction with the ECS: CBD’s approach is more indirect. It has a low binding affinity for CB1 and CB2 receptors. Instead, it is thought to work by inhibiting the FAAH enzyme, which is responsible for breaking down anandamide. By slowing this breakdown, CBD may increase the levels of the body’s own endocannabinoids, allowing them to exert more influence and promote a state of balance.
• Broad Influence: CBD’s interaction with the body is complex, which may help explain its role in supporting a sense of calm and well-being*.
• Primary Supported Uses: Due to its role as a holistic system balancer, CBD is an ideal foundational supplement for anyone looking to manage everyday stress*, support recovery from exercise*, and promote overall health and wellness*.

CBN (Cannabinol): The Sleep-Supporting Cannabinoid

CBN is unique in both its origin and its primary application. It is not directly synthesized by the hemp plant in large quantities. Instead, CBN is formed when THC ages and breaks down due to exposure to oxygen and heat. This makes it a minor cannabinoid, but one with distinct and powerful properties.

• Interaction with the ECS: CBN is understood to have a mild affinity for the CB1 receptor, but its interaction is different from that of THC. It does not produce a significant intoxicating effect. Instead, this interaction is what is believed to contribute to its ability to support rest and relaxation*
• The “Sleepy” Cannabinoid: Of all the cannabinoids, CBN is most strongly associated with sleep. Many users seek it out as a natural way to support a healthy sleep cycle*.
• Primary Supported Uses: CBN may offer some benefits for individuals whose primary goal is to support relaxation and a healthy sleep cycle*. It is best taken in the evening to help prepare the mind and body for rest.

CBD vs. CBN vs. CBG: A Head-to-Head Comparison Table

This table provides a direct comparison of the key attributes of CBD, CBN, and CBG based on NuLeaf Naturals’ full-spectrum products, helping you easily distinguish their functions and recommended uses.

Which Cannabinoid is Right for You? In-Depth Scenarios

To choose the correct cannabinoid, match your wellness goal to its primary benefits.

Choose CBD For General Wellness and Recovery

• Scenario: You have a demanding job, a busy family life, and you try to fit in workouts a few times a week. You often feel worn down by daily stressors and notice your muscles are sore longer than you’d like. Your goal is not to target one specific issue, but to feel more balanced, resilient, and centered overall. 
• Solution: CBD is an ideal foundational supplement for you. By supporting your body’s ECS, it helps you manage everyday stress* and aids in recovery*. Taking it daily can promote a sense of calm and balance*.

Shop our Full Spectrum CBD products

Choose CBN For Dedicated Sleep Support

• Scenario: You are looking to better prepare for rest at the end of a long day. Your goal is to unwind in the evening and support a more consistent night-time routine. 
• Solution: CBN is well-suited for your situation*. Its properties are ideal for evening use to promote relaxation and support a healthy sleep cycle*, helping you wind down before bed. 

Shop our Full Spectrum CBN products

Choose CBG For Foundational Wellness and Recovery

• Scenario: You are looking for a daily supplement to support your overall wellness, similar to CBD, but are particularly interested in supporting recovery from exercise* and maintaining focus throughout the day*. 
• Solution: CBG is an excellent choice. It supports the body’s overall wellness and recovery processes* and is uniquely suited for those who want to support mental clarity throughout the day*.

Shop our Full Spectrum CBG products

The Power of Combination: The Entourage Effect Explained

You do not have to choose just one cannabinoid. The “entourage effect” is a scientific theory that proposes cannabinoids are more effective when consumed together. Think of it like an orchestra: while a solo violin (an isolate) can be beautiful, the sound of the entire orchestra playing in harmony (a full-spectrum extract) is far richer and more complex.

In a full-spectrum product, cannabinoids like CBD, CBN, and CBG work in synergy. They are joined by other beneficial plant compounds, including:

• Terpenes:Aromatic compounds that give plants their unique scents (like lavender or pine) and contribute to the overall effect of the extract.
• Flavonoids: Phytonutrients that contribute to the plant’s color and possess antioxidant properties.

This whole-plant approach makes sure you receive a symphony of compounds working in concert to supercharge your endocannabinoid system, providing a more comprehensive effect than any single compound could alone.

Frequently Asked Questions (FAQ)

Can I fail a drug test from taking these products? 

A: NuLeaf Naturals’ full-spectrum products are derived from hemp and contain THC levels below the legal limit of 0.3%. While it is unlikely, the consumption of any hemp product containing trace amounts of THC could potentially lead to a positive result on a drug test. If you are subject to drug testing, we recommend consulting with your healthcare provider or employer.

How long does it take to feel the effects of the oils? 

When taken sublingually (under the tongue), effects can typically be felt within 15-45 minutes. However, the most notable effects* often come from consistent, daily use, as it allows the cannabinoids to accumulate in your system and support your ECS more effectively*.

What is the difference in how CBD, CBN, and CBG feel?

CBD and CBG are non-intoxicating and primarily support a sense of balance and well-being. Users often report feeling more ‘centered’ or ‘calm’ with CBD, and more ‘focused’ with CBG*. CBN is known for its relaxing and sleep-supporting qualities*, and users often take it in the evening when preparing for bed.”

Can I take CBD, CBN, and CBG together? 

Yes. Taking them together can produce the entourage effect, where the compounds work synergistically to improve each other’s benefits*. We offer Multicannabinoid products designed for this purpose.

How much should I take? 

NuLeaf Naturals suggests a starting dose of ten drops (30mg) daily. It is best to start with the recommended dose for several days, observe how your body feels, and then adjust as needed. If you need guidance, the NuLeaf Naturals Expert Team is available to coach you through the process.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.