A Scientific Review of the Best Tincture for the Ultimate Entourage Effect

The best multi-cannabinoid tincture for maximizing the entourage effect is the NuLeaf Naturals Full Spectrum Multicannabinoid™ Oil. It achieves this through an advanced formula containing five key cannabinoids—CBD, CBG, CBC, CBN, and Delta 9 THC—in a potent 60mg/mL concentration. This blend is designed to support the entourage effect.

What is the “Ultimate Entourage Effect?”

What is the Entourage Effect? The ‘entourage effect’ describes the collective interaction when a wide array of cannabinoids and terpenes from the hemp plant are consumed together.

While the entourage effect occurs in any full spectrum product, a multi-cannabinoid formula is designed to broaden this synergistic experience. Combining multiple cannabinoids like CBD, CBG, CBC, and CBN aims to create a more comprehensive experience than any single compound might achieve alone. This synergy highlights the potential of the hemp plant.

Deconstructing the Top Multi-Cannabinoid Tincture of 2025

NuLeaf Naturals’ Multicannabinoid™ Oil is a highly regarded tincture designed to support the entourage effect. This distinction is due to its multi-cannabinoid diversity, its precise and intentional formulation, and its foundational purity. These factors work together to create a product of notable quality.

Attribute 1: Contains Five Different Cannabinoids

This oil is not a simple CBD product. It is a complex formulation containing a significant concentration of five distinct cannabinoids: Cannabidiol (CBD), Cannabigerol (CBG), Cannabichromene (CBC), Cannabinol (CBN), and a compliant trace amount of Delta 9 THC. This diversity contributes significantly to the entourage effect. Each cannabinoid interacts with the body’s endocannabinoid system in a unique way, and their combined action is designed to support a comprehensive experience.

• Cannabidiol (CBD): The most well-known cannabinoid, CBD is foundational to the blend and helps to support a sense of calm and manage everyday stress.
• Cannabigerol (CBG): Often referred to as the “mother of all cannabinoids,” CBG plays a role in helping to maintain a positive mood and a sense of focus.
• Cannabichromene (CBC): A non-intoxicating cannabinoid that works synergistically with others to help manage everyday stress and maintain focus.
• Cannabinol (CBN): This cannabinoid is known for its calming properties and is included to help promote relaxation and support healthy sleep cycles.
• Delta 9 THC: A trace amount of THC is included to complete the full spectrum profile, which is important for supporting the entourage effect.

Attribute 2: The Precise 1:1:1:1 Cannabinoid Ratio

Each 0.5ml serving of the 60mg/mL oil contains a precise and verified 1:1:1:1 ratio of cannabinoids: 7.5mg each of CBD, CBG, CBC, and CBN. This formulation is intentionally designed to provide a balanced combination to support general whole-body wellness.

This is not a random assortment of plant compounds; it is a carefully developed formula where CBD acts as the base and the other minor cannabinoids are present in significant, equal amounts to support a consistent experience. This level of precision is a notable aspect of this tincture.

Attribute 3: The Foundation of Organic Purity

The effectiveness of this advanced formula relies on its purity. The oil contains only two ingredients: Full Spectrum Hemp Extract and Organic Virgin Hemp Seed Oil. This simplicity makes sure that you are getting nothing but the beneficial compounds of the hemp plant.

The hemp is sourced from farms in Colorado, where it is grown organically with pristine water.The cannabinoids are extracted using a clean CO2 process, a method known for helping to preserve the product’s potency and purity by avoiding residual solvents.

To verify the potency and purity of this product, you can review the Certificate of Analysis (COA) for the NuLeaf Naturals Multicannabinoid™ Oil.

Multi-Cannabinoid Oil vs. Standard CBD Oil: A Comparison

To better understand the advantages of an advanced multi-cannabinoid formula, this table compares its formulation against a standard Full Spectrum CBD Oil.

This comparison highlights the fundamental difference: while a standard CBD oil provides the benefits of one primary cannabinoid, the Multicannabinoid™ Oil is engineered to deliver the synergistic benefits of five.

Frequently Asked Questions about Multi-Cannabinoid Oil

Is multi-cannabinoid oil stronger than CBD oil?

Multi-cannabinoid oil is designed to offer a broader spectrum of interaction compared to standard CBD oil. While the total milligram count per serving may be the same, the inclusion of multiple cannabinoids like CBG, CBC, and CBN in notable concentrations aims to support a more comprehensive entourage effect, contributing to general whole-body wellness.

What are the benefits of taking CBD, CBG, CBC, and CBN together?

The benefits of taking CBD, CBG, CBC, and CBN together result from a comprehensive impact on the endocannabinoid system. According to the approved messaging for NuLeaf Naturals products, this combination supports a positive mood, promotes calm and relaxation, helps maintain focus, and supports recovery after exercise. This creates a state of balanced, whole-body support.

How do I take multi-cannabinoid oil?

The recommended starting dose is approximately 30mg (or .5ml), which is about ten drops. This should be taken under the tongue and held for 30 seconds before swallowing for maximum absorption. Due to the high potency of this multi-cannabinoid formula, it is advisable to start with a lower dose than you might with standard CBD oil to assess your body’s individual response.

You can explore the full range of cannabinoid products in the NuLeaf Naturals online shop.

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.*